%0 Journal Article %T Effects of Dietary Nucleotide Supplementation on Growth Performance, Internal Organs, Blood Metabolites, and HIF-1α mRNA Expression in Ascites Induced Broiler Chickens %J Poultry Science Journal %I Gorgan University of Agricultural Sciences and Natural Resources %Z 2345-6604 %A Safaei, M %A Hassanabadi, A %D 2020 %\ 11/01/2020 %V 8 %N 2 %P 135-143 %! Effects of Dietary Nucleotide Supplementation on Growth Performance, Internal Organs, Blood Metabolites, and HIF-1α mRNA Expression in Ascites Induced Broiler Chickens %K Ascites %K Nucleotide %K Broiler chicken %K Gene expression %R 10.22069/psj.2020.17228.1512 %X This experiment was conducted to study the effects of nucleotide supplementation on induced ascites and its effects on growth performance, blood metabolites, and expression of hypoxia-inducible factor 1α (HIF-1α) mRNA in Ross 308 broiler chickens. A total of 672 one-day-old Ross 308 broiler chicks were allocated to eight treatments with two levels of common salt in drinking water (0 and 2 g/lit) and four dietary supplemental levels of nucleotides (0, 0.5, 1, and 2 g/kg diet). Each treatment was included 7 replicates of 12 birds each. The experimental design was completely randomized in a factorial arrangement. In this study, 0.2% salt in drinking water induced ascites, decreased body weight (BW), and increased mortality, right ventricle (RV) weight as well as RV to total ventricles ratio (P < 0.05). Results showed that nucleotide levels of 0.05 and 0.1% significantly decreased RV weight and blood triiodothyronine (T3) concentration on 42 d. Interaction effects between salt and nucleotide supplement revealed that 0.1% nucleotide level in the salt group significantly reduced blood T3 concentration in comparison with non-nucleotide supplemented and normal water group. Feed intake, weight gain, feed conversion ratio, carcass characteristics, and the expression of HIF-1α mRNA in heart of broilers were not significantly affected by excess salt, nucleotide supplement, and their interaction. It was concluded that 0.5 g/kg dietary nucleotide supplementation decreased the ascites parameter of the RV/BW ratio in broiler chickens. %U https://psj.gau.ac.ir/article_5197_ada14895ab843c8c87c1857bece9c110.pdf